HIV and Its Treatment
 Testing
HIV Positive – Do I Have AIDS?
Seeing
an HIV Doctor
Starting
Anti-HIV Medications
Recommended
HIV Treatment Regimens
Approved
Medications to Treat HIV Infection
Is
My Treatment Regimen Working?
HIV
Treatment Regimen Failure
Changing
My HIV Treatment Regimen
What
is Treatment Adherence?
Adhering
To My HIV Treatment Regimen
HIV
and Pregnancy
Understanding
HIV Prevention
Anti-HIV (also called antiretroviral) medications are used to control the reproduction of the virus and to slow the progression of HIV-related disease. Highly Active Antiretroviral Therapy (HAART) is the recommended treatment for HIV infection. HAART combines three or more anti-HIV medications in a daily regimen. Anti-HIV medications do not cure HIV infection and individuals taking these medications can still transmit HIV to others.
Anti-HIV medications fall into four classes:
| Class
| Generic Name |
Brand and Other Names |
Manufacturer |
FDA Approval Date |
| Nonnucleoside Reverse
Transcriptase Inhibitors (NNRTIs) |
| NNRTIs bind to and disable reverse
transcriptase, a protein that HIV needs to make more copies of
itself. |
|
|
|
Delavirdine
|
Rescriptor, DLV
|
Pfizer
|
April 4, 1997
|
| |
Efavirenz
|
Sustiva, EFV
|
Bristol-Myers Squibb
|
September 17, 1998
|
|
Nevirapine
|
Viramune, NVP
|
Boehringer Ingelheim
|
June 21, 1996
|
| |
| Nucleoside Reverse
Transcriptase Inhibitors (NRTIs) |
| NRTIs are faulty versions of building blocks
that HIV needs to make more copies of itself. When HIV uses an NRTI
instead of a normal building block, reproduction of the virus is
stalled. |
|
|
| |
Abacavir
|
Ziagen, ABC
|
GlaxoSmithKline
|
December 17, 1998
|
| |
Abacavir, Lamivudine, Zidovudine
|
Trizivir
|
GlaxoSmithKline
|
November 14, 2000
|
| |
Didanosine
|
Videx, ddI
Videx EC
|
Bristol-Myers Squibb
|
October 9, 1991
October 31, 2000
|
| |
Emtricitabine
|
Emtriva, FTC, Coviracil
|
Gilead Sciences
|
July 2, 2003
|
| |
Lamivudine
|
Epivir, 3TC
|
GlaxoSmithKline
|
November 17, 1995
|
| |
Lamivudine, Zidovudine
|
Combivir
|
GlaxoSmithKline
|
September 27, 1997
|
| |
Stavudine
|
Zerit, d4T
|
Bristol-Myers Squibb
|
June 24, 1994
|
| |
Tenofovir DF
|
Viread, TDF
|
Gilead Sciences
|
October 26, 2001
|
| |
Zalcitabine
|
Hivid, ddC
|
Hoffman-La Roche
|
June 19, 1992
|
| |
Zidovudine
|
Retrovir, AZT, ZDV
|
GlaxoSmithKline
|
March 19, 1987
|
| |
| Protease Inhibitors
(PIs) |
| PIs disable protease, a protein that HIV needs
to make more copies of itself. |
|
|
| |
Amprenavir
|
Agenerase, APV
|
GlaxoSmithKline, Vertex Pharmaceuticals
|
April 15, 1999
|
| |
Atazanavir
|
Reyataz, ATV
|
Bristol-Myers Squibb
|
June 20, 2003
|
| |
Fosamprenavir
|
Lexiva, FPV
|
GlaxoSmithKline, Vertex Pharmaceuticals
|
October 20, 2003
|
| |
Indinavir
|
Crixivan, IDV
|
Merck
|
March 13, 1996
|
| |
Lopinavir, Ritonavir
|
Kaletra, LPV/r
|
Abbott Laboratories
|
September 15, 2000
|
| |
Nelfinavir
|
Viracept, NFV
|
Agouron Pharmaceuticals
|
March 14, 1997
|
| |
Ritonavir
|
Norvir, RTV
|
Abbott Laboratories
|
March 1, 1996
|
| |
Saquinavir
|
Fortovase, SQV
Invirase
|
Hoffman-La Roche
|
November 7, 1997
December 6, 1995
|
| |
| Fusion
Inhibitors |
| Fusion Inhibitors prevent HIV entry into
cells. |
|
|
| |
Enfuvirtide
|
Fuzeon, T-20
|
Hoffman-La Roche, Trimeris
|
March 13, 2003
|
|
|
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