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Disorders Associated with Infertility

There are many disorders that affect a woman's ability to get pregnant. Some of these conditions include:

Polycystic Ovary Syndrome (PCOS)
Endometriosis
Premature Ovarian Failure (POF)/Ovarian Insufficiency
Uterine Fibroids

Polycystic Ovary Syndrome (PCOS)

PCOS is the most common cause of female infertility. A woman's ovaries have follicles, which are tiny, fluid-filled sacs that hold the eggs. When an egg is mature, the follicle breaks open to release the egg so it can travel to the uterus for fertilization. In women with PCOS, immature follicles bunch together to form large cysts or lumps. The eggs mature within the bunched follicles, but the follicles don't break open to release them. As a result, women with PCOS often don't have menstrual periods, or they only have periods now and then. Because the eggs are not released, most women with PCOS have trouble getting pregnant. Researchers estimate that 5 percent to 10 percent of women in the United States have PCOS.

Women with PCOS may also have other health problems, such as abnormally high levels of insulin, obesity, high blood pressure, and heart disease. A small number of these women will also gain weight and notice an increase in their hair growth.

Although researchers are still trying to learn about this disease, and to find ways to treat the infertility associated with PCOS, there have been some promising leads. 

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Endometriosis

Endometriosis occurs when tissue like that which lines the inside of the uterus grows outside the uterus. The two most common symptoms, pain and infertility, can deeply affect a woman's quality of life. In many cases, women who receive treatment for their endometriosis pain are able to get pregnant. But this is not the case for all women. 

Endometriosis is not a cancerous condition. Also, current research does not prove an association between endometriosis and uterine, cervical, endometrial, or ovarian cancers.

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Premature Ovarian Failure (POF)/Ovarian Insufficiency

Health care providers use the term POF to describe a stop in normal functioning of the ovaries in a woman under the age of 40. (Women's ovary function naturally begins to decline at age 40). In POF, the ovaries stop making eggs and stop making certain hormones. 

The most common first symptom of POF is having irregular periods. Health care providers sometimes overlook irregular or skipped periods as being related to stress. But a woman's monthly cycle is actually an important sign of her health, in the same way that blood pressure or temperature are signs of health. If you have irregular periods or skip periods, you should tell your health care provider, so that he or she can begin to find the cause of these problems.

Women with POF often have difficulty becoming pregnant because their ovaries aren't working correctly. There is currently no proven medical treatment that improves a woman's ability to have a baby naturally if she has POF. But, between 5 percent and 10 percent of women with POF do become pregnant, even though they have not had any fertility treatment. Sometimes pregnancy can occur decades after the initial diagnosis. Researchers cannot explain why some women with POF get pregnant, while others do not.

Women with POF are at greater risk for certain other health conditions, including Addison's disease, a condition in which the body does not respond well to physical stresses. This condition can be dangerous for women who don't know they have it. 

Women with POF are also at greater risk for osteoporosis. Estrogen is key to your body's ability to reach its peak bone mass and to preserve bone mineral density. Women who lack proper levels of estrogen, like those women who have POF, are at increased risk for the bone disease, and at much younger ages than would be expected. 

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Uterine Fibroids

Uterine fibroids are the most common, non-cancerous tumors in women of childbearing age. These tumors are made of muscle cells and other tissues that grow within the wall of the uterus. Fibroids can grow in different locations, including:

Just underneath the lining of the uterus, called submucosal (sub-myou-KO-sul)

In between the muscles of the uterus, called intramural (in-tra-MYOU-rel)

On the outside of the uterus, called subserosal (sub-sir-OH-sul)

Uterine fibroids are the cause of more than 200,000 hysterectomies each year.

The most common symptoms of fibroids are heavy bleeding or painful periods, bleeding between periods, a "full" feeling in the lower abdomen (sometimes called pelvic pressure), and urinating often. In some cases, fibroids may make it difficult for a woman to get pregnant naturally, although researchers don't know exactly why.

Uterine fibroids are not cancerous, nor are they associated with cancer. In very rare instances, less than 0.1 percent of cases, fibroids do develop into cancer.

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